Exosome therapy for skin problems and skin aging
In the world of skincare, new trends constantly emerge, some of which are firmly scientifically substantiated, while others are primarily based on hype. Exosomes appear to break this prejudice. Originally, these microscopic vesicles were the subject of research in medical science, for example for targeted drug delivery or wound healing. Meanwhile, various studies demonstrate that exosomes can also play a substantial role in skincare for skin regeneration, inflammation reduction, and skin rejuvenation.
What are exosomes and how do they work?
Exosomes are minuscule vesicles (30–150 nanometers) that are secreted by cells and function as messengers. Their action is based on three elements:
- The casing: a lipid bilayer with recognition proteins such as CD63 and CD81, which guide exosomes to specific target cells.
- The content: mRNA, microRNA, and epigenetic signals that regulate gene activity and influence cellular processes.
- The mechanism: Exosomes are taken up by skin cells and release their 'cargo'. This activates processes such as collagen production, inflammation inhibition, and cell renewal.
Exosomes not only tell skin cells what to do, but also improve their functional capacity.
Applications of exosomes in skin therapy:
Skin aging and sagging
Aging causes wrinkles, loss of elasticity, and thinner skin. Exosomes address this via:
- Stimulation of collagen and elastin production
- Antioxidative protection
- Strengthening the skin barrier
- Improve cell renewal and skin density
Rosacea and couperose
For redness and mild inflammation, exosome therapy has a calming and restorative effect:
- Reduces redness and visible blood vessels
- Supports sensitive skin
Scars (acne, surgical, burns)
Exosomes support scar repair by targeted stimulation of collagen and improving cell renewal, resulting in less visible scars.
Reduced skin elasticity
Firm skin requires healthy matrix proteins. Exosomes stimulate:
- Fibroblast activity
- Production of elastin and collagen
- Repair of damaged skin structures
Recovery after laser and microneedling treatments
After fractional Erbium Glass laser or microneedling, exosomes offer direct benefits:
- Faster recovery of skin structure
- Less redness and swelling
- Long-term stimulation of collagen
Pigment spots and melasma
Exosomes regulate pigment production and improve skin texture:
- Melanin production is normalized
- Refines texture, reduces stains
- Recurrence of pigment is prevented
Safety and origin of exosomes
At Medicadermis, I work exclusively with plant-based exosomes (for example, from tomato or ginger) and artificially produced nanobubbles. These are safe, effective, and free of foreign proteins.
Human exosomes are subject to ATMP regulations in the Netherlands and are only permitted within clinical studies.
Practical treatment for Medicadermis
The treatment begins with a comprehensive intake and dermatological examination. Afterwards, I apply microneedling or fractional laser. Immediately after the treatment, I apply the exosomes.The micropunctures or laser channels ensure that the active ingredients penetrate deep into the skin. During a follow-up session, I evaluate the effect and we tailor the subsequent treatment to your skin's needs.
Frequently Asked Questions
How quickly will I see results?
A first improvement is usually visible after 2 to 4 weeks.
How often is treatment needed?
On average 3 to 4 sessions with 3–4 weeks in between.
Is exosome therapy safe?
Yes, provided that plant-based or artificially manufactured exosomes are used.
Want to know more or receive personal advice?
Although large-scale long-term studies are still under development, existing publications offer a promising basis. At Medicademis, I translate these insights into a safe and effective approach tailored to your skin.
Schedule your free intake for exosome therapy here or feel free to send a message if you have any questions.
Sources
- Théry, C. et al. (2018). MISEV2018: Minimal information for studies of extracellular vesicles. Journal of Extracellular Vesicles, 7(1), 1535750.
- Park, GH et al. (2023). Efficacy of combined treatment with exosome–containing solution and microneedling. Journal of Cosmetic Dermatology, 22(12), 3418–3426.
- Kuehn, MJ & Kesty, N. C. (2005). Bacterial outer membrane vesicles. Genes & Development, 19(22), 2645–2655.