As a skin therapist, I follow new developments in the field of skin rejuvenation and repair with great interest. Innovations that bring biology and technology together particularly catch my attention. One of the ingredients that has been on the rise lately is PDRN, polydeoxyribonucleotide, a substance usually extracted from salmon seed. But what exactly does PDRN do for your skin, and what does science say about it?

Why is PDRN introduced into the skin via injections or microneedling?

PDRN is a biologically active DNA fragment with a high molecular weight and a water-loving (hydrophilic) structure. The skin barrier is specifically designed to keep these types of large substances out. Consequently, PDRN cannot passively penetrate the skin, as would be the case with a cream or serum.

For PDRN to be truly effective, it must be introduced into the deeper layers of the skin, particularly the dermis. This is done via injections (similar to mesotherapy or skin boosting), where it is delivered directly to the site of action. Another method is medical microneedling, in which micro-channels are created in the skin through which the PDRN can be absorbed transdermally.

In short: PDRN only works if it reaches the right spot in the skin, and that is not possible without a technique that temporarily opens the skin barrier.

What is PDRN from salmon DNA?

PDRN is a DNA fragment derived from the sperm cells of certain salmon species, such as Oncorhynchus mykiss or Oncorhynchus keta. These nucleotides, the building blocks of DNA, are often incorporated into serums, injectables, and microneedling treatments. The promise? Faster skin recovery, less inflammation, more collagen, and visibly younger-looking skin.

What does science say?

There are multiple studies demonstrating that PDRN supports certain repair processes in the skin:

• Wound healing: PDRN appears to stimulate fibroblast cell growth and promote angiogenesis (formation of new blood vessels). In a clinical study of leg ulcers, 67% of the PDRN group healed completely, compared to 22% in the control group.
• Collagen synthesis: PDRN activates the A2A adenosine receptor, which leads to increased production of collagen and elastin.
• Anti-inflammatory: It reduces pro-inflammatory cytokines, an important benefit for sensitive or reactive skin.

The applications are diverse: from support during laser recovery and microneedling to experimental use for scars and even hair loss.

But… are there any caveats?

Yes. Most studies are small in design or conducted under the direction of manufacturers. Independent, large-scale studies in humans are still limited. Moreover, there is no consensus on the ideal concentration or dosage form. It therefore remains important to remain critical and not blindly accept everything promised in commercial texts.

And what about the salmon?

As a skin therapist, I feel a social responsibility to also consider the origin of ingredients. PDRN is typically extracted from salmon sperm cells, without the animal having to die. However, this raises ethical questions: where do these salmon come from? Is the production process sustainable? Are they farmed fish or wild populations?

PDRN is typically extracted from the seminal fluid (the spleen) of male salmon. This is done via a technique called stripping, in which the sperm is manually squeezed out of the abdominal cavity of a living fish. In theory, this can take place without the animal being injured or killed, and this method is also used in fish farming for artificial insemination.In practice, however, these salmon are often used only once and subsequently slaughtered or processed anyway, particularly in industrial production for medical or cosmetic applications. There are no binding rules guaranteeing that the process is painless, stress-free, or sustainable. Transparency from producers is usually lacking, making it unclear exactly under what conditions the animals are kept and processed. This makes it difficult to substantiate claims regarding animal welfare or sustainability with certainty.

Fortunately, alternative sources are currently under development, such as microbially produced PDRN from Lactobacillus-tribes, a step forward for those who prefer cruelty-free or vegan skincare.

My vision as a skin therapist

I embrace innovation, but always with both feet on the ground. At Medicadermis I work exclusively with techniques and ingredients that align with my professional knowledge, scientific guidelines, and ethical compass. PDRN is undoubtedly an interesting development, but not a miracle cure.

It is not a substitute for a healthy skincare routine or proven therapies; however, provided it is applied correctly, it can be a supplement. Transparency, safety, and informed choices are paramount.

Are you considering treatment with PDRN?

Would you like to know if a PDRN treatment suits your skin type, recovery goal, or ethical conviction? I would be happy to assess the situation with you and explain what is possible and what is not. You will receive honest advice based on experience and science.

Take contact us for a no-obligation intake interview or schedule a video consultation.

Do you feel like something is still missing, or would you like to know something specific about this topic? Feel free to send me a message; I would be happy to include it in a future blog post.